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Glycerolipid signals alter mTOR complex 2 (mTORC2) to diminish insulin signaling
Increased flux through the glycerolipid synthesis pathway impairs the ability of insulin to inhibit hepatic gluconeogenesis, but the exact mechanism remains unknown. To determine the mechanism by which glycerolipids impair insulin signaling, we overexpressed glycerol-3-phosphate acyltransferase-1 (G...
में बचाया:
| मुख्य लेखकों: | , , , , , |
|---|---|
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
National Academy of Sciences
2012
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3277174/ https://ncbi.nlm.nih.gov/pubmed/22307628 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1110730109 |
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