Activation of mTORC1/mTORC2 signaling in pediatric low-grade glioma and pilocytic astrocytoma reveals mTOR as a therapeutic target

BACKGROUND: Previous studies support a role for mitogen-activated protein kinase pathway signaling, and more recently Akt/mammalian target of rapamycin (mTOR), in pediatric low-grade glioma (PLGG), including pilocytic astrocytoma (PA). Here we further evaluate the role of the mTORC1/mTORC2 pathway i...

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Detalhes bibliográficos
Main Authors: Hütt-Cabezas, Marianne, Karajannis, Matthias A., Zagzag, David, Shah, Smit, Horkayne-Szakaly, Iren, Rushing, Elisabeth J., Cameron, J. Douglas, Jain, Deepali, Eberhart, Charles G., Raabe, Eric H., Rodriguez, Fausto J.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
Assuntos:
Basic and Translational Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3829599/
https://ncbi.nlm.nih.gov/pubmed/24203892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/not132
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