LGG-52. DUAL INHIBITION OF mTORC1/C2 AND MEK PATHWAY IS SYNERGISTIC IN MULTIPLE HUMAN MODELS OF PEDIATRIC LOW-GRADE GLIOMA INCLUDING A NOVEL PATIENT-DERIVED NF1 PILOCYTIC ASTROCYTOMA CELL LINE

Pediatric low-grade glioma (PLGG) is the most common brain tumor of childhood. We and others have identified mTORC and MEK-activation in PLGG. The dual mTORC1/2-inhibitor, TAK228, and the FDA approved MEK-inhibitor, trametinib, are promising candidates for targeted PLGG therapy. We treated five diff...

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Veröffentlicht in:Neuro Oncol
Hauptverfasser: Arnold, Antje, Yuan, Ming, Rodriguez, Fausto, Eberhart, Charles, Raabe, Eric
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6012000/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy059.393
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