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Glycerolipid signals alter mTOR complex 2 (mTORC2) to diminish insulin signaling

Increased flux through the glycerolipid synthesis pathway impairs the ability of insulin to inhibit hepatic gluconeogenesis, but the exact mechanism remains unknown. To determine the mechanism by which glycerolipids impair insulin signaling, we overexpressed glycerol-3-phosphate acyltransferase-1 (G...

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Autors principals: Zhang, Chongben, Wendel, Angela A., Keogh, Matthew R., Harris, Thurl E., Chen, Jie, Coleman, Rosalind A.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3277174/
https://ncbi.nlm.nih.gov/pubmed/22307628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1110730109
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