Inhibition of DNA Synthesis by a Platinum–Acridine Hybrid Agent Leads to Potent Cell Kill in Nonsmall Cell Lung Cancer

[Image: see text] The platinum–acridine anticancer agent [PtCl(en)(LH)](NO(3))(2) (1) [en = ethane-1,2-diamine, LH = N-(2-(acridin-9-ylamino)ethyl)-N-methylpropionimidamide, acridinium cation] and the clinical drug cisplatin were studied in chemoresistant nonsmall cell lung cancer (NSCLC) cell lines...

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Hlavní autoři: Smyre, Christopher L., Saluta, Gilda, Kute, Timothy E., Kucera, Gregory L., Bierbach, Ulrich
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2011
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3274750/
https://ncbi.nlm.nih.gov/pubmed/22328962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml2001888
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