Synthesis and biological evaluation of platinum–acridine hybrid agents modified with bipyridine nonleaving groups

The use of 2,2´-bipyridines (4,4´-R(2)-2,2´-bpy; R = H, Me, OMe, CF(3)) as nonleaving groups (L-L) in platinum–acridinylthiourea conjugates, [PtCl(L-L)(ACRAMTU)](NO(3))(2), has been investigated. All bpy-substituted complexes (2–5) show micromolar activity in HL-60 (leukemia) and H460 (lung) cancer...

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Hauptverfasser: Kheradi, Alexander R., Saluta, Gilda, Kucera, Gregory L., Day, Cynthia S., Bierbach, Ulrich
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2800953/
https://ncbi.nlm.nih.gov/pubmed/19477643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.05.046
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