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Synthesis and biological evaluation of platinum–acridine hybrid agents modified with bipyridine nonleaving groups
The use of 2,2´-bipyridines (4,4´-R(2)-2,2´-bpy; R = H, Me, OMe, CF(3)) as nonleaving groups (L-L) in platinum–acridinylthiourea conjugates, [PtCl(L-L)(ACRAMTU)](NO(3))(2), has been investigated. All bpy-substituted complexes (2–5) show micromolar activity in HL-60 (leukemia) and H460 (lung) cancer...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2800953/ https://ncbi.nlm.nih.gov/pubmed/19477643 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.05.046 |
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