A Non-Cross-Linking Platinum–Acridine Agent with Potent Activity in Non-Small Cell Lung Cancer

The cytotoxic complex, [PtCl(Am)(2)(ACRAMTU)](NO(3))(2) (1) ((Am)(2) = ethane-1,2-diamine, en; ACRAMTU = 1-[2-(acridin-9-ylamino)ethyl]-1,3-dimethylthiourea), is a dual platinating/intercalating DNA binder that, unlike clinical platinum agents, does not induce DNA cross-links. Here, we demonstrate t...

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Detalhes bibliográficos
Main Authors: Ma, Zhidong, Choudhury, Jayati Roy, Wright, Marcus W., Day, Cynthia S., Saluta, Gilda, Kucera, Gregory L., Bierbach, Ulrich
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2743007/
https://ncbi.nlm.nih.gov/pubmed/19012390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm800900g
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