Tuning the DNA Conformational Perturbations Induced by Cytotoxic Platinum-Acridine Bisintercalators: Effect of Metal cis/trans Isomerism and DNA Threading Groups

Four highly charged, water soluble platinum-acridine bisintercalating agents have been synthesized. Depending on the cis/trans isomerism of the metal and the nature of the acridine side chains, bisintercalation induces/stabilizes the classical Watson-Crick B-form or a non-B-form. Circular dichroism...

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Bibliographic Details
Main Authors: Choudhury, Jayati Roy, Guddneppanavar, Rajsekhar, Saluta, Gilda, Kucera, Gregory L., Bierbach, Ulrich
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2697572/
https://ncbi.nlm.nih.gov/pubmed/18457380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm8003569
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