Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ: Visualizing the therapeutic effects of metformin in tumor tissue

We have recently proposed a new mechanism for explaining energy transfer in cancer metabolism. In this scenario, cancer cells behave as metabolic parasites, by extracting nutrients from normal host cells, such as fibroblasts, via the secretion of hydrogen peroxide as the initial trigger. Oxidative s...

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Bibliographic Details
Main Authors: Whitaker-Menezes, Diana, Martinez-Outschoorn, Ubaldo E, Flomenberg, Neal, Birbe, Ruth C, Witkiewicz, Agnieszka K, Howell, Anthony, Pavlides, Stephanos, Tsirigos, Aristotelis, Ertel, Adam, Pestell, Richard G, Broda, Paolo, Minetti, Carlo, Lisanti, Michael P, Sotgia, Federica
Format: Artigo
Language:Inglês
Published: Landes Bioscience 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3272287/
https://ncbi.nlm.nih.gov/pubmed/22134189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.10.23.18151
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