Is cancer a metabolic rebellion against host aging?: In the quest for immortality, tumor cells try to save themselves by boosting mitochondrial metabolism

Aging drives large systemic reductions in oxidative mitochondrial function, shifting the entire body metabolically toward aerobic glycolysis, a.k.a, the Warburg effect. Aging is also one of the most significant risk factors for the development of human cancers, including breast tumors. How are these...

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Main Authors: Ertel, Adam, Tsirigos, Aristotelis, Whitaker-Menezes, Diana, Birbe, Ruth C, Pavlides, Stephanos, Martinez-Outschoorn, Ubaldo E, Pestell, Richard G, Howell, Anthony, Sotgia, Federica, Lisanti, Michael P
Format: Artigo
Jezik:Inglês
Izdano: Landes Bioscience 2012
Teme:
Perspective
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3293377/
https://ncbi.nlm.nih.gov/pubmed/22234241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.11.2.19006
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