Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ: Visualizing the therapeutic effects of metformin in tumor tissue

We have recently proposed a new mechanism for explaining energy transfer in cancer metabolism. In this scenario, cancer cells behave as metabolic parasites, by extracting nutrients from normal host cells, such as fibroblasts, via the secretion of hydrogen peroxide as the initial trigger. Oxidative s...

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Autori principali: Whitaker-Menezes, Diana, Martinez-Outschoorn, Ubaldo E, Flomenberg, Neal, Birbe, Ruth C, Witkiewicz, Agnieszka K, Howell, Anthony, Pavlides, Stephanos, Tsirigos, Aristotelis, Ertel, Adam, Pestell, Richard G, Broda, Paolo, Minetti, Carlo, Lisanti, Michael P, Sotgia, Federica
Natura: Artigo
Lingua:Inglês
Pubblicazione: Landes Bioscience 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3272287/
https://ncbi.nlm.nih.gov/pubmed/22134189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.10.23.18151
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