Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ: Visualizing the therapeutic effects of metformin in tumor tissue

We have recently proposed a new mechanism for explaining energy transfer in cancer metabolism. In this scenario, cancer cells behave as metabolic parasites, by extracting nutrients from normal host cells, such as fibroblasts, via the secretion of hydrogen peroxide as the initial trigger. Oxidative s...

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Detalhes bibliográficos
Main Authors: Whitaker-Menezes, Diana, Martinez-Outschoorn, Ubaldo E, Flomenberg, Neal, Birbe, Ruth C, Witkiewicz, Agnieszka K, Howell, Anthony, Pavlides, Stephanos, Tsirigos, Aristotelis, Ertel, Adam, Pestell, Richard G, Broda, Paolo, Minetti, Carlo, Lisanti, Michael P, Sotgia, Federica
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2011
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Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3272287/
https://ncbi.nlm.nih.gov/pubmed/22134189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.10.23.18151
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