Ketones and lactate increase cancer cell “stemness”, driving recurrence, metastasis and poor clinical outcome in breast cancer: Achieving personalized medicine via metabolo-genomics

Previously, we showed that high-energy metabolites (lactate and ketones) “fuel” tumor growth and experimental metastasis in an in vivo xenograft model, most likely by driving oxidative mitochondrial metabolism in breast cancer cells. To mechanistically understand how these metabolites affect tumor c...

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Bibliografiske detaljer
Main Authors: Martinez-Outschoorn, Ubaldo E, Prisco, Marco, Ertel, Adam, Tsirigos, Aristotelis, Lin, Zhao, Pavlides, Stephanos, Wang, Chengwang, Flomenberg, Neal, Knudsen, Erik S, Howell, Anthony, Pestell, Richard G, Sotgia, Federica, Lisanti, Michael P
Format: Artigo
Sprog:Inglês
Udgivet: Landes Bioscience 2011
Fag:
Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3117136/
https://ncbi.nlm.nih.gov/pubmed/21512313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.10.8.15330
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