Activation-induced cytidine deaminase (AID)-dependent somatic hypermutation requires a splice isoform of the serine/arginine-rich (SR) protein SRSF1

Somatic hypermutation (SHM) of Ig variable region (IgV) genes requires both IgV transcription and the enzyme activation-induced cytidine deaminase (AID). Identification of a cofactor responsible for the fact that IgV genes are much more sensitive to AID-induced mutagenesis than other genes is a key...

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Detalhes bibliográficos
Main Authors: Kanehiro, Yuichi, Todo, Kagefumi, Negishi, Misaki, Fukuoka, Junji, Gan, Wenjian, Hikasa, Takuya, Kaga, Yoshiaki, Takemoto, Masayuki, Magari, Masaki, Li, Xialu, Manley, James L., Ohmori, Hitoshi, Kanayama, Naoki
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3268305/
https://ncbi.nlm.nih.gov/pubmed/22232677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1120368109
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