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Genetic manipulation of an exogenous non-immunoglobulin protein by gene conversion machinery in a chicken B cell line
During culture, a chicken B cell line DT40 spontaneously mutates immunoglobulin (Ig) genes by gene conversion, which involves activation-induced cytidine deaminase (AID)-dependent homologous recombination of the variable (V) region gene with upstream pseudo-V genes. To explore whether this mutation...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1342040/ https://ncbi.nlm.nih.gov/pubmed/16421270 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gnj013 |
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