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The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA
High mutation frequency during reverse transcription has a principal role in the genetic variation of primate lentiviral populations. It is the main driving force for the generation of drug resistance and the escape from immune surveillance. G to A hypermutation is one of the characteristics of prim...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2003
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1350966/ https://ncbi.nlm.nih.gov/pubmed/12808465 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature01707 |
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