Dissociation between duration of action in the forced swim test and nicotinic acetylcholine receptor occupancy with sazetidine, varenicline, and 5-I-A85380

RATIONALE: Nicotinic acetylcholine receptor (nAChR) agonists, partial agonists and antagonists have antidepressant-like effects in rodent models and reduce symptoms of depression in humans. OBJECTIVE: The aim of this study was to determine if the β2* partial agonist sazetidine-A (sazetidine) showed...

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Autors principals: Caldarone, Barbara J., Wang, Daguang, Paterson, Neil E., Manzano, Michael, Fedolak, Allison, Cavino, Katie, Kwan, Mei, Hanania, Taleen, Chellappan, Sheela K., Kozikowski, Alan P., Olivier, Berend, Picciotto, Marina R., Ghavami, Afshin
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3266849/
https://ncbi.nlm.nih.gov/pubmed/21487659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-011-2271-y
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