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Silencing of DLC1 Upregulates PAI-1 Expression and Reduces Migration in Normal Prostate Cells

Deleted in liver cancer 1 (DLC1) is a GTPase activating protein (GAP) domain containing tumor suppressor that localizes to focal adhesions. In cancer cells, loss of DLC1 is known to enhance cancer cell migration. However, the role of DLC1 in normal cell migration has not been well studied. Here, we...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Shih, Yi-Ping, Takada, Yoshikazu, Lo, Su Hao
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3262057/
https://ncbi.nlm.nih.gov/pubmed/22064653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-11-0450
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