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Tensin1 positively regulates RhoA activity through its interaction with DLC1
DLC1 is a RhoGAP-containing tumor suppressor and many of DLC1’s functions are absolutely dependent on its RhoGAP activity. Through its RhoGAP domain, DLC1 inhibits the activity of RhoA GTPase, which regulates actin cytoskeleton networks and dis/assembly of focal adhesions. Tensin1 (TNS1) is a focal...
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| Veröffentlicht in: | Biochim Biophys Acta |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4621260/ https://ncbi.nlm.nih.gov/pubmed/26427649 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamcr.2015.09.028 |
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