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Tensin1 positively regulates RhoA activity through its interaction with DLC1

DLC1 is a RhoGAP-containing tumor suppressor and many of DLC1’s functions are absolutely dependent on its RhoGAP activity. Through its RhoGAP domain, DLC1 inhibits the activity of RhoA GTPase, which regulates actin cytoskeleton networks and dis/assembly of focal adhesions. Tensin1 (TNS1) is a focal...

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Bibliografiske detaljer
Udgivet i:Biochim Biophys Acta
Main Authors: Shih, Yi-Ping, Sun, Peng, Wang, Aifeng, Lo, Su Hao
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4621260/
https://ncbi.nlm.nih.gov/pubmed/26427649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamcr.2015.09.028
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