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Tensin1 positively regulates RhoA activity through its interaction with DLC1

DLC1 is a RhoGAP-containing tumor suppressor and many of DLC1’s functions are absolutely dependent on its RhoGAP activity. Through its RhoGAP domain, DLC1 inhibits the activity of RhoA GTPase, which regulates actin cytoskeleton networks and dis/assembly of focal adhesions. Tensin1 (TNS1) is a focal...

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Publicat a:Biochim Biophys Acta
Autors principals: Shih, Yi-Ping, Sun, Peng, Wang, Aifeng, Lo, Su Hao
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4621260/
https://ncbi.nlm.nih.gov/pubmed/26427649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamcr.2015.09.028
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