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Metal Ion Substrate Inhibition of Ferrochelatase

Ferrochelatase catalyzes the insertion of ferrous iron into protoporphyrin IX to form heme. Robust kinetic analyses of the reaction mechanism are complicated by the instability of ferrous iron in aqueous solution, particularly at alkaline pH values. At pH 7.00 the half-life for spontaneous oxidation...

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Autori principali: Hunter, Gregory A., Sampson, Matthew P., Ferreira, Gloria C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3259753/
https://ncbi.nlm.nih.gov/pubmed/18593702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803372200
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