Metal Ion Substrate Inhibition of Ferrochelatase

Ferrochelatase catalyzes the insertion of ferrous iron into protoporphyrin IX to form heme. Robust kinetic analyses of the reaction mechanism are complicated by the instability of ferrous iron in aqueous solution, particularly at alkaline pH values. At pH 7.00 the half-life for spontaneous oxidation...

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Hlavní autoři: Hunter, Gregory A., Sampson, Matthew P., Ferreira, Gloria C.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2008
Témata:
Enzyme Catalysis and Regulation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3259753/
https://ncbi.nlm.nih.gov/pubmed/18593702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803372200
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