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Direct measurement of metal ion chelation in the active site of human ferrochelatase

The final step in heme biosynthesis, insertion of ferrous iron into protoporphyrin IX, is catalyzed by protoporphyrin IX ferrochelatase (E.C. 4.99.1.1). It is demonstrated that the pre-steady state human ferrochelatase (R115L) shows a stoichiometric burst of product formation and substrate consumpti...

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Detalhes bibliográficos
Main Authors: Hoggins, M., Dailey, H.A., Hunter, C.N., Reid, J.D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2396339/
https://ncbi.nlm.nih.gov/pubmed/17566985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi602418e
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