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Direct measurement of metal ion chelation in the active site of human ferrochelatase

The final step in heme biosynthesis, insertion of ferrous iron into protoporphyrin IX, is catalyzed by protoporphyrin IX ferrochelatase (E.C. 4.99.1.1). It is demonstrated that the pre-steady state human ferrochelatase (R115L) shows a stoichiometric burst of product formation and substrate consumpti...

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Bibliografiska uppgifter
Huvudupphovsmän: Hoggins, M., Dailey, H.A., Hunter, C.N., Reid, J.D.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2007
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2396339/
https://ncbi.nlm.nih.gov/pubmed/17566985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi602418e
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