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Direct measurement of metal ion chelation in the active site of human ferrochelatase

The final step in heme biosynthesis, insertion of ferrous iron into protoporphyrin IX, is catalyzed by protoporphyrin IX ferrochelatase (E.C. 4.99.1.1). It is demonstrated that the pre-steady state human ferrochelatase (R115L) shows a stoichiometric burst of product formation and substrate consumpti...

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Bibliografiske detaljer
Main Authors: Hoggins, M., Dailey, H.A., Hunter, C.N., Reid, J.D.
Format: Artigo
Sprog:Inglês
Udgivet: 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2396339/
https://ncbi.nlm.nih.gov/pubmed/17566985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi602418e
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