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Direct measurement of metal ion chelation in the active site of human ferrochelatase

The final step in heme biosynthesis, insertion of ferrous iron into protoporphyrin IX, is catalyzed by protoporphyrin IX ferrochelatase (E.C. 4.99.1.1). It is demonstrated that the pre-steady state human ferrochelatase (R115L) shows a stoichiometric burst of product formation and substrate consumpti...

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Autors principals: Hoggins, M., Dailey, H.A., Hunter, C.N., Reid, J.D.
Format: Artigo
Idioma:Inglês
Publicat: 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2396339/
https://ncbi.nlm.nih.gov/pubmed/17566985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi602418e
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