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Metal Ion Selectivity and Substrate Inhibition in the Metal Ion Chelation Catalyzed by Human Ferrochelatase

Protoporphyrin IX ferrochelatase (EC 4.99.1.1) catalyzes the terminal step in the heme biosynthetic pathway, the insertion of ferrous iron into protoporphyrin IX. Ferrochelatase shows specificity, in vitro, for multiple metal ion substrates and exhibits substrate inhibition in the case of zinc, copp...

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Autors principals: Davidson, Ruth E., Chesters, Christopher J., Reid, James D.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2788750/
https://ncbi.nlm.nih.gov/pubmed/19767646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.030205
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