Substrate Recognition Mechanism of VAMP/Synaptobrevin-cleaving Clostridial Neurotoxins

Botulinum neurotoxins (BoNTs) and tetanus neurotoxin (TeNT) inhibit neurotransmitter release by proteolyzing a single peptide bond in one of the three soluble N-ethylmaleimide-sensitive factor attachment protein receptors SNAP-25, syntaxin, and vesicle-associated membrane protein (VAMP)/synaptobrevi...

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Bibliographic Details
Main Authors: Sikorra, Stefan, Henke, Tina, Galli, Thierry, Binz, Thomas
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2008
Subjects:
Enzyme Catalysis and Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3258937/
https://ncbi.nlm.nih.gov/pubmed/18511418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800610200
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