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Clostridial Neurotoxins: Mechanism of SNARE Cleavage and Outlook on Potential Substrate Specificity Reengineering

The clostridial neurotoxin family consists of tetanus neurotoxin and seven distinct botulinum neurotoxins which cause the diseases tetanus and botulism. The extreme potency of these toxins primarily relies not only on their ability to specifically enter motoneurons but also on the activity their cat...

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Bibliographic Details
Main Authors: Binz, Thomas, Sikorra, Stefan, Mahrhold, Stefan
Format: Artigo
Language:Inglês
Published: Molecular Diversity Preservation International 2010
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3153214/
https://ncbi.nlm.nih.gov/pubmed/22069605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/toxins2040665
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