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Receptor and substrate interactions of clostridial neurotoxins
The high potency of clostridial neurotoxins relies predominantly on their neurospecific binding and specific hydrolysis of SNARE proteins. Their multi step mode of mechanism can be ascribed to their multi-domain three-dimensional structure. The C-terminal H(CC)-domain interacts subsequently with com...
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| Главные авторы: | , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2009
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2756235/ https://ncbi.nlm.nih.gov/pubmed/19268493 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxicon.2008.12.027 |
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