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Substrate Recognition of VAMP-2 by Botulinum Neurotoxin B and Tetanus Neurotoxin
Botulinum neurotoxin (BoNT; serotypes A-G) and tetanus neurotoxin elicit flaccid and spastic paralysis, respectively. These neurotoxins are zinc proteases that cleave SNARE proteins to inhibit synaptic vesicle fusion to the plasma membrane. Although BoNT/B and tetanus neurotoxin (TeNT) cleave VAMP-2...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2475686/ https://ncbi.nlm.nih.gov/pubmed/18511417 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800611200 |
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