Substrate Recognition of VAMP-2 by Botulinum Neurotoxin B and Tetanus Neurotoxin

Botulinum neurotoxin (BoNT; serotypes A-G) and tetanus neurotoxin elicit flaccid and spastic paralysis, respectively. These neurotoxins are zinc proteases that cleave SNARE proteins to inhibit synaptic vesicle fusion to the plasma membrane. Although BoNT/B and tetanus neurotoxin (TeNT) cleave VAMP-2...

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Bibliographic Details
Main Authors: Chen, Sheng, Hall, Cherisse, Barbieri, Joseph T.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2008
Subjects:
Protein Synthesis, Post-Translational Modification, and Degradation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2475686/
https://ncbi.nlm.nih.gov/pubmed/18511417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800611200
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