7,8-Dichloro-1-oxo-β-carbolines as a Versatile Scaffold for the Development of Potent and Selective Kinase Inhibitors with Unusual Binding Modes†

[Image: see text] Development of both potent and selective kinase inhibitors is a challenging task in modern drug discovery. The innate promiscuity of kinase inhibitors largely results from ATP-mimetic binding to the kinase hinge region. We present a novel class of substituted 7,8-dichloro-1-oxo-β-c...

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Bibliografiske detaljer
Main Authors:	Huber, Kilian, Brault, Laurent, Fedorov, Oleg, Gasser, Christelle, Filippakopoulos, Panagis, Bullock, Alex N., Fabbro, Doriano, Trappe, Jörg, Schwaller, Jürg, Knapp, Stefan, Bracher, Franz
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Chemical Society 2011
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3257585/ https://ncbi.nlm.nih.gov/pubmed/22136433 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm201286z
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7,8-Dichloro-1-oxo-β-carbolines as a Versatile Scaffold for the Development of Potent and Selective Kinase Inhibitors with Unusual Binding Modes†

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