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Metal-mediated affinity and orientation specificity in a computationally designed protein homodimer
Computationally designing protein-protein interactions with high affinity and desired orientation is a challenging task. Incorporating metal-binding sites at the target interface may be one approach for increasing affinity and specifying the binding mode, thereby improving robustness of designed int...
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| Autores principales: | , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3257401/ https://ncbi.nlm.nih.gov/pubmed/22092237 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja208015j |
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