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Probing the minimal determinants of zinc binding with computational protein design

Structure-based protein design tests our understanding of the minimal determinants of protein structure and function. Previous studies have demonstrated that placing zinc binding amino acids (His, Glu, Asp or Cys) near each other in a folded protein in an arrangement predicted to be tetrahedral is o...

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Dettagli Bibliografici
Pubblicato in:Protein Eng Des Sel
Autori principali: Guffy, Sharon L., Der, Bryan S., Kuhlman, Brian
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2016
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4955873/
https://ncbi.nlm.nih.gov/pubmed/27358168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzw026
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