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Combined computational design of a zinc binding site and a protein-protein interaction: one open zinc coordination sphere was not a robust hotspot for de novo ubiquitin binding
We computationally designed a de novo protein-protein interaction between wild-type ubiquitin and a redesigned scaffold. Our strategy was to incorporate zinc at the designed interface to promote affinity and orientation specificity. A large set of monomeric scaffold surfaces were computationally eng...
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| Hlavní autoři: | , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2013
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4084500/ https://ncbi.nlm.nih.gov/pubmed/23504819 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.24280 |
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