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Engineering a protein–protein interface using a computationally designed library

Computational algorithms for protein design can sample large regions of sequence space, but suffer from undersampling of conformational space and energy function inaccuracies. Experimental screening of combinatorial protein libraries avoids the need for accurate energy functions, but has limited acc...

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Библиографические подробности
Главные авторы: Guntas, Gurkan, Purbeck, Carrie, Kuhlman, Brian
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2010
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2984139/
https://ncbi.nlm.nih.gov/pubmed/20974935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1006528107
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