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Engineering a protein–protein interface using a computationally designed library
Computational algorithms for protein design can sample large regions of sequence space, but suffer from undersampling of conformational space and energy function inaccuracies. Experimental screening of combinatorial protein libraries avoids the need for accurate energy functions, but has limited acc...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2984139/ https://ncbi.nlm.nih.gov/pubmed/20974935 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1006528107 |
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