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Incorporation of noncanonical amino acids into Rosetta and use in computational protein-peptide interface design.

Noncanonical amino acids (NCAAs) can be used in a variety of protein design contexts. For example, they can be used in place of the canonical amino acids (CAAs) to improve the biophysical properties of peptides that target protein interfaces. We describe the incorporation of 114 NCAAs into the prote...

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Bibliografiske detaljer
Main Authors: P Douglas Renfrew, Eun Jung Choi, Richard Bonneau, Brian Kuhlman
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science (PLoS) 2012-01-01
Serier:PLoS ONE
Online adgang:http://europepmc.org/articles/PMC3303795?pdf=render
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