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Computational Design of the Sequence and Structure of a Protein-Binding Peptide
The de novo design of protein-binding peptides is challenging, because it requires identifying both a sequence and a backbone conformation favorable for binding. We used a computational strategy that iterates between structure and sequence optimization to redesign the C-terminal portion of the RGS14...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3081598/ https://ncbi.nlm.nih.gov/pubmed/21388199 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja110296z |
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