Blocking IL-21 signaling ameliorates xenogeneic GVHD induced by human lymphocytes

In rodent graft-versus-host disease (GVHD) models, anti–IL-21 neutralizing mAb treatment ameliorates lethality and is associated with decreases in Th1 cytokine production and gastrointestinal tract injury. GVHD prevention was dependent on the in vivo generation of donor-inducible regulatory T cells...

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Detaylı Bibliyografya
Asıl Yazarlar: Hippen, Keli L., Bucher, Christoph, Schirm, Dawn K., Bearl, Amanda M., Brender, Ty, Mink, Kathy A., Waggie, Kimberly S., Peffault de Latour, Regis, Janin, Anne, Curtsinger, Julie M., Dillon, Stacey R., Miller, Jeffrey S., Socie, Gerard, Blazar, Bruce R.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society of Hematology 2012
Konular:
Immunobiology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3257019/
https://ncbi.nlm.nih.gov/pubmed/22077059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-07-368027
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