Blocking IL-21 signaling ameliorates xenogeneic GVHD induced by human lymphocytes

In rodent graft-versus-host disease (GVHD) models, anti–IL-21 neutralizing mAb treatment ameliorates lethality and is associated with decreases in Th1 cytokine production and gastrointestinal tract injury. GVHD prevention was dependent on the in vivo generation of donor-inducible regulatory T cells...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Hippen, Keli L., Bucher, Christoph, Schirm, Dawn K., Bearl, Amanda M., Brender, Ty, Mink, Kathy A., Waggie, Kimberly S., Peffault de Latour, Regis, Janin, Anne, Curtsinger, Julie M., Dillon, Stacey R., Miller, Jeffrey S., Socie, Gerard, Blazar, Bruce R.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society of Hematology 2012
Gaiak:
Immunobiology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3257019/
https://ncbi.nlm.nih.gov/pubmed/22077059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-07-368027
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