Preclinical testing of anti-human CD28 Fab’ antibody in a novel nonhuman primate (NHP) small animal rodent model of xenogenic graft-versus-host disease (GVHD)

BACKGROUND: Graft-versus-host disease (GVHD) is a severe complication of hematopoietic stem cell transplantation. Current therapies to prevent alloreactive T cell activation largely cause generalized immunosuppression and may result in adverse drug, anti-leukemia and anti-pathogen responses. Recentl...

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Detalhes bibliográficos
Publicado no:Transplantation
Main Authors: Hippen, Keli L., Watkins, Benjamin, Tkachev, Victor, Lemire, Amanda M., Lehnen, Charles, Riddle, Megan J., Singh, Karnail, Panoskaltsis-Mortari, Angela, Vanhove, Bernard, Tolar, Jakub, Kean, Leslie S., Blazar, Bruce R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5175408/
https://ncbi.nlm.nih.gov/pubmed/27861291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TP.0000000000001465
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