Differential effects of proteasome inhibition by bortezomib on murine acute graft-versus-host disease (GVHD): delayed administration of bortezomib results in increased GVHD-dependent gastrointestinal toxicity

We have recently demonstrated that the proteasome inhibitor, bortezomib, administered immediately following murine allogeneic bone marrow transplantation (BMT) resulted in marked inhibition of acute graft-versus-host disease (GVHD) with retention of graft-versus-tumor effects. We now assessed the ef...

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Autors principals: Sun, Kai, Wilkins, Danice E. C., Anver, Miriam R., Sayers, Thomas J., Panoskaltsis-Mortari, Angela, Blazar, Bruce R., Welniak, Lisbeth A., Murphy, William J.
Format: Artigo
Idioma:Inglês
Publicat: © 2005 by The American Society of Hematology 2005
Matèries:
Transplantation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895334/
https://ncbi.nlm.nih.gov/pubmed/15961519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2004-11-4526
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