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IL-10 exacerbates xenogeneic GVHD by inducing massive human T cell expansion
Although patients with GVHD have elevated serum levels of IL10, whether its role is protective or pathogenic remains unclear. Here, we used a humanized mouse model to study the role of IL-10 in GVHD. When human PBMCs were engrafted in NOD-scid IL2rγc(null) mice expressing human IL-10, the T cells un...
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| Veröffentlicht in: | Clin Immunol |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4310723/ https://ncbi.nlm.nih.gov/pubmed/25463432 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clim.2014.11.004 |
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