Combination of IL-10 and IL-2 induces oligoclonal human CD4 T cell expansion during xenogeneic and allogeneic GVHD in humanized mice

IL-10 is a crucial anti-inflammatory cytokine which can also exert a seemingly divergent immunostimulatory effects under certain conditions. We found high levels of the cytokine in a xenogeneic GVHD model where NOD-scid IL2rγcnull (NSG) mice were transplanted with human PBMCs in presence of IL-2. Pr...

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Detalhes bibliográficos
Main Authors: Sojan Abraham, Hua Guo, Jang-gi Choi, Chunting Ye, Midhun Ben Thomas, Nora Ortega, Alok Dwivedi, N. Manjunath, Guohua Yi, Premlata Shankar
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017-04-01
Colecção:Heliyon
Assuntos:
Biological sciences
Immunology
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2405844016318898
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