Blocking IL-21 signaling ameliorates xenogeneic GVHD induced by human lymphocytes

In rodent graft-versus-host disease (GVHD) models, anti–IL-21 neutralizing mAb treatment ameliorates lethality and is associated with decreases in Th1 cytokine production and gastrointestinal tract injury. GVHD prevention was dependent on the in vivo generation of donor-inducible regulatory T cells...

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Bibliografiske detaljer
Main Authors: Hippen, Keli L., Bucher, Christoph, Schirm, Dawn K., Bearl, Amanda M., Brender, Ty, Mink, Kathy A., Waggie, Kimberly S., Peffault de Latour, Regis, Janin, Anne, Curtsinger, Julie M., Dillon, Stacey R., Miller, Jeffrey S., Socie, Gerard, Blazar, Bruce R.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2012
Fag:
Immunobiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3257019/
https://ncbi.nlm.nih.gov/pubmed/22077059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-07-368027
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