Discovery of a Novel Class of Orally Active Trypanocidal N-Myristoyltransferase Inhibitors

[Image: see text] N-Myristoyltransferase (NMT) represents a promising drug target for human African trypanosomiasis (HAT), which is caused by the parasitic protozoa Trypanosoma brucei. We report the optimization of a high throughput screening hit (1) to give a lead molecule DDD85646 (63), which has...

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Bibliografski detalji
Glavni autori: Brand, Stephen, Cleghorn, Laura A. T., McElroy, Stuart P., Robinson, David A., Smith, Victoria C., Hallyburton, Irene, Harrison, Justin R., Norcross, Neil R., Spinks, Daniel, Bayliss, Tracy, Norval, Suzanne, Stojanovski, Laste, Torrie, Leah S., Frearson, Julie A., Brenk, Ruth, Fairlamb, Alan H., Ferguson, Michael A. J., Read, Kevin D., Wyatt, Paul G., Gilbert, Ian H.
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2011
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3256935/
https://ncbi.nlm.nih.gov/pubmed/22148754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm201091t
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