Adenovirus i-Leader Truncation Bioselected Against Cancer-associated Fibroblasts to Overcome Tumor Stromal Barriers

Tumor-associated stromal cells constitute a major hurdle in the antitumor efficacy with oncolytic adenoviruses. To overcome this biological barrier, an in vitro bioselection of a mutagenized AdwtRGD stock in human cancer-associated fibroblasts (CAFs) was performed. Several rounds of harvest at early...

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Detaylı Bibliyografya
Asıl Yazarlar: Puig-Saus, Cristina, Gros, Alena, Alemany, Ramon, Cascalló, Manel
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2012
Konular:
Original Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3255593/
https://ncbi.nlm.nih.gov/pubmed/21863000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.159
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