Hyaluronidase Expression by an Oncolytic Adenovirus Enhances Its Intratumoral Spread and Suppresses Tumor Growth

Successful virotherapy requires efficient virus spread within tumors. We tested whether the expression of hyaluronidase, an enzyme which dissociates the extracellular matrix (ECM), could enhance the intratumoral distribution of an oncolytic adenovirus and improve its therapeutic activity. As a proof...

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Bibliographic Details
Main Authors: Guedan, Sonia, Rojas, Juan José, Gros, Alena, Mercade, Elena, Cascallo, Manel, Alemany, Ramon
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2010
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2911260/
https://ncbi.nlm.nih.gov/pubmed/20442708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.79
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