Minimal RB-responsive E1A Promoter Modification to Attain Potency, Selectivity, and Transgene-arming Capacity in Oncolytic Adenoviruses

Oncolytic adenoviruses are promising anticancer agents due to their ability to self-amplify at the tumor mass. However, tumor stroma imposes barriers difficult to overcome by these agents. Transgene expression is a valuable strategy to counteract these limitations and to enhance antitumor activity....

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Hlavní autoři: Rojas, Juan J, Guedan, Sonia, Searle, Peter F, Martinez-Quintanilla, Jordi, Gil-Hoyos, Raúl, Alcayaga-Miranda, Francisca, Cascallo, Manel, Alemany, Ramon
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2010
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2990517/
https://ncbi.nlm.nih.gov/pubmed/20808288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.173
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