Developing Novel Oncolytic Adenoviruses through Bioselection

Mutants of human adenovirus 5 (Ad5) with enhanced oncolytic activity were isolated by using a procedure termed bioselection. Two mutants, ONYX-201 and ONYX-203, were plaque purified from a pool of randomly mutagenized Ad5 that was repeatedly passaged in the human colorectal cancer cell line HT29, an...

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Detalhes bibliográficos
Main Authors: Yan, Wen, Kitzes, Galila, Dormishian, Farid, Hawkins, Lynda, Sampson-Johannes, Adam, Watanabe, Josh, Holt, Jenny, Lee, Vivian, Dubensky, Thomas, Fattaey, Ali, Hermiston, Terry, Balmain, Allan, Shen, Yuqiao
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Recombination and Evolution
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC141112/
https://ncbi.nlm.nih.gov/pubmed/12552003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.4.2640-2650.2003
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