GLI1 inhibition promotes epithelial-to-mesenchymal transition in pancreatic cancer cells

The Hedgehog (HH) pathway has been identified as an important deregulated signal transduction pathway in pancreatic ductal adenocarcinoma (PDAC), a cancer type characterized by a highly metastatic phenotype. In PDAC, the canonical HH pathway activity is restricted to the stromal compartment while HH...

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Main Authors: Joost, Simon, Almada, Luciana L., Rohnalter, Verena, Holz, Philipp S., Vrabel, Anne M., Fernandez-Barrena, Maite G., McWilliams, Robert R., Krause, Michael, Fernandez-Zapico, Martin E., Lauth, Matthias
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3251693/
https://ncbi.nlm.nih.gov/pubmed/22086851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-4621
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