Development of Neh2-Luciferase Reporter and Its Application for High Throughput Screening and Real-Time Monitoring of Nrf2 Activators

The NF-E2-related factor 2 (Nrf2) is a key transcriptional regulator of antioxidant defense and detoxification. To directly monitor stabilization of Nrf2, we fused its Neh2 domain, responsible for the interaction with its nucleocytoplasmic regulator, Keap1, to firefly luciferase (Neh2-luciferase). W...

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Hoofdauteurs: Smirnova, Natalya A., Haskew-Layton, Renee E., Basso, Manuela, Hushpulian, Dmitry M., Payappilly, Jimmy B., Speer, Rachel E., Ahn, Young-Hoon, Rakhman, Ilay, Cole, Philip A., Pinto, John T., Ratan, Rajiv R., Gazaryan, Irina G.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2011
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3251032/
https://ncbi.nlm.nih.gov/pubmed/21700211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2011.03.013
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